应数学系刘胜强教授的邀请，信阳师范学院数学与统计学院王霞副教授将于将于2018年6月26日-7月2日来公司进行学术交流，并于6月29下午举办种病毒动力系统数学模型与分析讲座，欢迎公司相关专业的老师和同学参加。

报告题目：HIV Models with Multiple Infection Stages and Antiretroviral Therapy

时        间：2018年6月29下午14:30-15:30

地        点：格物楼503室

报告摘要：In this paper, we develop a general mathematical model incorporating multiple infection stages and various drug classes that can interfere with specific stages of the viral life cycle. We derive the basic reproductive number and obtain the global stability results of steady states. Using several simple cases of the general model, we study the effect of various drug classes on the dynamics of HIV decay. When drugs are assumed to be 100% effective, drugs acting later in the viral life cycle lead to a faster or more rapid decay in viremia. This is consistent with some patient and experimental data, and also agrees with previous modeling results. When drugs are not 100% effective, the viral decay dynamics are more complicated. Without a second population of long-lived infected cells, the viral load decline can have two phases if drugs act at an intermediate stage of the viral replication cycle. The slopes of viral load decline depend on the drug effectiveness, the death rate of infected cells at different stages, and the transition rate of infected cells from one to the next stage. With a second population of long-lived infected cells, the viral load decline can have three distinct phases, consistent with the observation in patients receiving antiretroviral therapy containing the integrase inhibitor raltegravir. We also fit modeling prediction to patient data under efavirenz and raltegravir treatment. 

专家简介： 王霞，现任信阳师范学院数学与统计学院副教授。2013年于002全讯白菜网获得博士学位，导师为刘胜强教授。2014年5月-2016年12 月在陕西师范大学数学与信息科学院从事博士后工作；曾先后访问美国奥克兰大学、香港理工大学、美国佛罗里达大学。研究领域包括生物数学、病毒动力系统，迄今在Bull.Math.Biol.、J.Theor.Biol.等知名学术期刊发表SCI收录论文30余篇。先后承担国家自然科学基金青年项目和面上项目各1项、主持中国博士后基金项目、国家留学基金委公派留学项目、陕西省博士后基金（特等资助）、河南省高校科技创新人才支持计划、信阳师范学院首届“南湖学者奖励计划”青年项目等。